Beefalo
In the 18th century, settlers accidentally crossed bison and cattle when they first brought the latter to the New World. They were later crossbred more intentionally, but a couple of them got loose. You will now find wild herds of the beefalo close to the Grand Canyon. They wreak havoc by emptying watering holes and making a mess no matter where they go! It is now a debate if we should capture them.
Tigon
The Tigon is the result of a cross between a male tiger and a female lion. The sex of the parents is what makes it different from a Liger. You would think that the tigon and the liger would look similar, but they are quite different. Tigons do not grow to be as big as ligers, nor do they typically develop dwarfism. Overall, they are healthier than their close cousins.